Increased age was also associated with decreased activity in the bilateral parietal and occipital lobes as well as the right temporal lobe and right motor areas.Ĭonclusion and Relevance: This imaging study characterizes the brain activity underlying performance of the CDT in a healthy older aging population using the most naturalistic version of the task to date. Increased age was significantly correlated with Rouleau scores on the clock number drawing (R2) component (rho = -0.55, p < 0.001) the clock hand drawing (R3) component (rho = -0.50, p < 0.005) and the total clock (rho = -0.62, p < 0.001). Activation was observed in the bilateral frontal, occipital and parietal lobes as well as the supplementary motor area and precentral gyri. Results: Study findings are reported for 33 cognitively healthy older participants aged 52–85. To assess convergent validity, performance during fMRI was compared to performance on a standard paper version of the task, administered in a psychometric testing room. Performance on the CDT was evaluated using a standardized scoring system (Rouleau score) and time to test completion.
Brain activity during CDT performance was contrasted to rest periods of visual fixation. Main Outcome and Measure: Blood-oxygen-level dependent (BOLD) functional MRI was conducted as participants completed the CDT using novel tablet technology. Purpose: To administer the CDT naturalistically to a healthy older aging population in an MRI environment, and characterize the brain activity associated with test completion. Behavioral performance on the test has been studied extensively, but there is scant literature on the underlying neural correlates. Importance: The clock-drawing test (CDT) is an important neurocognitive assessment tool, widely used as a screening test for dementia. 7Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.5Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.4Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.3Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada.2Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.1Keenan Research Centre for Biomedical Science, St.
Hird 1,2, Iryna Pshonyak 1, Fred Tam 3, Corinne E.
0 kommentar(er)
